Contortrostatin CN and methods for its use in preventing metastasis and other conditions

摘要

Contortrostatin, a homodimeric disintegrin, modulates the adhesion, motility, and invasiveness of integrin expressing tumor cells. When formulated as a pharmaceutically acceptable composition, the proteins can be used to treat patients by inhibiting or disrupting disease processes associated with an integrin binding to an alphavbeta3 or alphavbeta5 integrin.