| 发明名称 |
PIPERAZINE DERIVATIVES |
| 摘要 |
A piperazine derivative of the formula I (see formula I) in which R1 may be substituted pyridyl or phenyl, and R2 may be monosubstituted or unsubstituted pyridyl, pyrimidinyl or pyrazinyl or substituted phenyl. The piperazine derivative is a dopamine ligand with a selectivity for the D4 receptor and is suitable for the treatment and prophylaxis of states of anxiety, depression, schizophrenia, obsessions, Parkinson's disease, tardive dyskinesia, nausea and disorders of the gastro-intestinal tract.
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| 申请公布号 |
CA2266050(C) |
申请公布日期 |
2007.05.22 |
| 申请号 |
CA19972266050 |
申请日期 |
1997.09.03 |
| 申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
BOTTCHER, HENNING;ARLT, MICHAEL;BARTOSZYK, GERD;SEYFRIED, CHRISTOPH |
| 分类号 |
C07D213/38;C07D295/02;A61K31/444;A61K31/495;A61K31/496;A61K31/505;A61K31/506;A61P25/00;A61P43/00;C07D213/74;C07D239/42;C07D241/04;C07D295/04;C07D295/06;C07D295/073;C07D295/096;C07D295/155;C07D307/82;C07D401/12;C07D405/12;C07D409/10;C07D409/12;C07D409/14 |
主分类号 |
C07D213/38 |
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