发明名称 |
Preparation of (E)- and (Z)-2-methyl-2-butenoic acids |
摘要 |
A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to (E)-2-methyl-2-butenoic acid (2M2BA) using enzyme catalysts having either a nitrilase activity or a combination of nitrile hydratase and amidase activities. The method provides high yields without significant conversion of (Z)-2M2BN to (Z)-2M2BA. The regioselective hydrolysis of (E)-2M2BN to (E)-2M2BA makes possible the facile separation of (E)-2M2BA from (Z)-2M2BN or (Z)-2-methyl-2-butenamide (2M2BAm), and the subsequent conversion of (Z)-2M2BN or (Z)-2M2BAm to (Z)-2M2BA.
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申请公布号 |
US7220562(B2) |
申请公布日期 |
2007.05.22 |
申请号 |
US20060338471 |
申请日期 |
2006.01.24 |
申请人 |
E. I. DU PONT DE NEMOURS AND COMPANY |
发明人 |
BRAMUCCI MICHAEL G.;DICOSIMO ROBERT;CHAUHAN SARITA;FALLON ROBERT D.;GAVAGAN JOHN E.;PAYNE MARK S. |
分类号 |
C12P13/00;C07H21/04;C07K14/00;C12N1/20;C12N1/21;C12N9/78;C12N9/80;C12N9/88;C12N11/02;C12N11/14;C12N15/00;C12P7/40;C12P41/00;C12Q1/34 |
主分类号 |
C12P13/00 |
代理机构 |
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地址 |
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