发明名称 Self-assembling recombinant papillomavirus capsid proteins
摘要 Recombinant papillomavirus capsid proteins that are capable of self assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.
申请公布号 US7220419(B2) 申请公布日期 2007.05.22
申请号 US20030371846 申请日期 2003.02.21
申请人 THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 发明人 LOWY DOUGLAS R.;SCHILLER JOHN T.;KIRNBAUER REINHARD
分类号 A61K39/12;G01N33/53;A61K39/00;A61K39/23;A61P17/12;A61P31/12;A61P31/20;A61P35/00;C07K14/025;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N7/04;C12N15/09;C12N15/37;C12P21/02;C12Q1/70;C12R1/91;G01N33/566;G01N33/569 主分类号 A61K39/12
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