发明名称 |
Enhanced gamma-carboxylation of recombinant vitamin K-dependent clotting factor |
摘要 |
The invention relates to methods of optimizing gamma carboxylation of a vitamin K-dependent protein, methods of generating fully gamma carboxylated vitamin K-dependent protein, and compositions comprising chimeric nucleic acids and proteins for use in treatment of vitamin K-dependent disease states.
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申请公布号 |
US7220849(B2) |
申请公布日期 |
2007.05.22 |
申请号 |
US20030349858 |
申请日期 |
2003.01.22 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA |
发明人 |
HIGH KATHERINE A.;CAMIRE RODNEY M.;LARSON PETER J.;STAFFORD DARREL W. |
分类号 |
C12N5/10;A61K35/12;A61K38/00;A61K48/00;C12N9/64;C12N15/12;C12N15/85 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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