USE OF CICLETANINE AND OTHER FUROPYRIDINES FOR TREATMENT OF SYSTOLIC-PREDOMINANT HYPERTENSION, ISOLATED SYSTOLIC HYPERTENSION, ELEVATED PULSE PRESSURE AND GENERAL HYPERTENSION

摘要

This invention provides compositions of cicletanine and other furopyridines for treatment of elevated pulse pressure, isolated systolic hypertension, and general hypertension, in monotherapeutic forms (furopyridine-only) and in compositions combined with other antihypertensive agents, cardiovascular agents, and/or oral antidiabetic agents. Such furopyridine compositions include enantiomerically pure (positive or negative) embodiments and non-racemic enantiomeric mixtures, and include daily dosages of less than 50 mg. Further provided are methods of treatment of general or systolic hypertension, patients being administered the furopyridine compositions alone or in combination with a second agent for treatment of general hypertension or systolic hypertension, and associated complications.