发明名称 |
DRUG-ELUTING STENTS COATED WITH NON-NUCLEOTIDE P2Y12 RECEPTOR ANTAGONIST COMPOUND |
摘要 |
<p>This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The present invention also provides a drug-eluting stent, wherein the stent is coated with one or more non-mucleotide P2Y<SUB>12</SUB> receptor antagonist compounds or a pharmaceutically acceptable salt, solvate, or hydrate thereof. When the stent is placed in a narrowed or damaged blood vessel, a therapeutically effective amount of the P2Y<SUB>12</SUB> receptor antagonist compound is eluted continuously from the stent to the local environment of the stent. The P2Y<SUB>12</SUB> receptor antagonist compound-eluting stents are useful in preventing thrombosis and restenosis, and are effective in inhibiting thrombus formation, inhibiting the contraction of vascular smooth muscle cells, inhibiting cell proliferation, and reducing inflammation.</p> |
申请公布号 |
WO2007056217(A2) |
申请公布日期 |
2007.05.18 |
申请号 |
WO2006US43089 |
申请日期 |
2006.11.02 |
申请人 |
INSPIRE PHARMACEUTICALS, INC.;BOYER, JOSE L.;DOUGLASS, JAMES G., III;SHAVER, SAMMY R. |
发明人 |
BOYER, JOSE L.;DOUGLASS, JAMES G., III;SHAVER, SAMMY R. |
分类号 |
A61K31/519;A61F2/00;A61K31/52 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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