发明名称 |
METHODS OF SENSITIZING CANCER TO THERAPY-INDUCED CYTOTOXICITY |
摘要 |
<p>The present application demonstrates that Salinosporamide A can be used to sensitize cancer cells to cancer therapy. Furthermore, the present application demonstrates that Salinosporamide A acts as a therapeutic agent to kill or inhibit cancer cells after sensitization of the cells by an antibody or other chemosensitizing reagents. The cancer cells can be either therapy-sensitive or therapy resistant. The present application further demonstrates that Salinosporamide A induces the expression of Raf kinase inihibitor protein (RKIP) and PTEN, tumor suppressor proteins, and inhibits the expression of YYl, a transcriptional regulator protein overexpressed in cancer cells and also inhibits the growth factor pleiotrophin (PTN).</p> |
申请公布号 |
WO2007056335(A2) |
申请公布日期 |
2007.05.18 |
申请号 |
WO2006US43277 |
申请日期 |
2006.11.06 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;NEREUS PHARMACEUTICALS;BONAVIDA, BENJAMIN;PALLADINO, MICHAEL |
发明人 |
BONAVIDA, BENJAMIN;PALLADINO, MICHAEL |
分类号 |
A61K31/43 |
主分类号 |
A61K31/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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