摘要 |
<p>The present invention is characterized by the use of Mas G- protein-coupled receptor agonists and antagonists as apoptotic activity modulators for study, prevention and treatment of diseases. It is further characterized by the use of Mas G-protein-coupled receptor agonist and antagonists for modulation of the apoptotic activity involving alterations in the activity of the protein kinase B/Akt. Another characteristic of the invention is the use of Mas G-protein-coupled receptor agonists and antagonists, including the Ang- (1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, as modulators of apoptotic activity for study, prevention and treatment of degenerative diseases of organs and systems, as an auxiliary measure for organs transplantation, treatment with embryonic, non- embryonic stem cells, re-implantation of organs and tissues and other treatments that need temporary or chronic reduction of the apoptotic activity, not limitative. The invention further claims the use of Mas G-protein-coupled receptor agonists and antagonists, including the Angiotensin-(1-7) peptide and its analogues, agonists and antagonists, either peptidic or non-peptidic, formulated with pharmaceutically and pharmacologically acceptable excipients or carriers, as modulators of the apoptotic activity.</p> |
申请人 |
UNIVERSIDADE FEDERAL DE MINAS GERAIS;SOUZA DOS SANTOS, ROBSON AUGUSTO;VELOSO BRANT PINHEIRO, SERGIO;DE FARIA E SILVA, RAPHAEL;SILVA LULA, IVANA;BARROS DE SOUSA, FREDERICO;FREZARD, FREDERIC JEAN GEORGES;DOS REIS, ADELINA MARTHA;DE FRANCA, LUIZ RENATO;FERREIRA, ANDERSON, JOSE;SINISTERRA, RUBEN DARIO;CAMPAGNOLE-SANTOS, MARIA JOSE;DE OLIVEIRA SAMPAIO, WALKYRIA NEYDE;DE CASTRO LEAL, MARCELO;KAPPES BECKER, LENICE |
发明人 |
SOUZA DOS SANTOS, ROBSON AUGUSTO;VELOSO BRANT PINHEIRO, SERGIO;DE FARIA E SILVA, RAPHAEL;SILVA LULA, IVANA;BARROS DE SOUSA, FREDERICO;FREZARD, FREDERIC JEAN GEORGES;DOS REIS, ADELINA MARTHA;DE FRANCA, LUIZ RENATO;FERREIRA, ANDERSON, JOSE;SINISTERRA, RUBEN DARIO;CAMPAGNOLE-SANTOS, MARIA JOSE;DE OLIVEIRA SAMPAIO, WALKYRIA NEYDE;DE CASTRO LEAL, MARCELO;KAPPES BECKER, LENICE |