发明名称 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF NAV1.8GENE
摘要 <p num="1"><br/><br/><br/>The invention relates to a double-stranded ribonucleic acid (dsRNA) for <br/>inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an <br/>antisense strand having a nucleotide sequence which is less that 25 <br/>nucleotides in length and which is substantially complementary to at least a <br/>part of the Nav1.8 gene. The invention also relates to a pharmaceutical <br/>composition comprising the dsRNA together with a pharmaceutically acceptable <br/>carrier; methods for treating diseases caused by the expression of the Nav1.8 <br/>gene using the pharmaceutical composition; and methods for inhibiting the <br/>expression of the Nav1.8 gene gene in a cell<br/>
申请公布号 CA2626584(A1) 申请公布日期 2007.05.18
申请号 CA20062626584 申请日期 2006.11.03
申请人 ALNYLAM PHARMACEUTICALS, INC. 发明人 FRANK-KAMENETSKY, MARIA;GEICK, ANKE;HADWIGER, PHILIPP;ROEHL, INGO;TAN, PAMELA;SAH, DINAH WEN-YEE;VORNLOCHER, HANS-PETER
分类号 A61K48/00;C07F9/6533;C07H21/02;C07J17/00;C12N5/10;C12N15/113 主分类号 A61K48/00
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