METHODS AND COMPOSITIONS FOR DETERMINING HYPERSUSCEPTIBILITY OF HIV-1 TO NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

摘要

This invention relates to methods for determining hypersusceptibility of HIV-1 viruses to non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding reverse transcriptase of the HIV-1, the presence of a mutation at codon 65, 69, or 74 alone or in combination with one or more mutations at certain other codons. Combinations of mutation associated with h ersusce tibilit to NNRTIs are also disclosed.