发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR V LEIDEN MUTANT GENE |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor V Leiden mutant gene (Factor V Leiden mutant gene), comprising an antisense strand having a nucleotide sequence which is less than 25 nucleotides in length and which is substantially complementary to at least a part of the Factor V Leiden mutant gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Factor V Leiden mutant gene using the pharmaceutical composition; and methods for inhibiting the expression of the Factor V Leiden mutant gene in a cell. |
申请公布号 |
CA2626690(A1) |
申请公布日期 |
2007.05.18 |
申请号 |
CA20062626690 |
申请日期 |
2006.11.07 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
MARAGANORE, JOHN M.;VORNLOCHER, HANS-PETER |
分类号 |
A61K48/00;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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