METHOD AND COMPOSITION FOR SKIN DEPIGMENTATION

摘要

The present invention relates to a compound of formula I: [(C)-(L')]_n-(A)-[(L)-(B)]_mwherein (A) is a thioglycosylated cysteine of formula IIa or IIb: IIa IIb; (B) is a melanogenosis-inhibiting peptide comprising peptide sequence selected from a group consisting of: (i). Glu-Asp-Tyr-His-Ser-Leu-Tyr-Gln-Ser-His-Leu; (ii). Ser-Gly-Gly-Tyr-Leu-Pro-Pro-Leu; and (iii). His-Ser-C(O)-NH-(CH2)k-CH2-C(O)-NH-Ser-His; (C) is a tyrosinase inhibitor; n is 0 or 1; m is 0 or 1; m + n is 1 or 2;k is 2-10; X1 is O or NH; R₁, R₂, R₇, and R₈ are each, independently, selected from H, and a bond in a linkage group between (A) and (L); R₃, R₄, R₅, R₆, R₉, R₁₀, R₁₁, and R₁₂ are each, independently, selected from H, a saccharide, and a bond in a linkage group between (A) and (L'); (L) is a linker which forms linkage groups with thioglycosylated cysteine (A) and melanogenosis-inhibiting peptide (B); and (L') is a linker which forms linkage groups with thioglycosylated cysteine (A) and tyrosinase inhibitor (C).