MOLECULAR DIAGNOSIS OF AUTOIMMUNE DISEASES

摘要

Methods for detecting a multiple sclerosis (MS) syndrome in a subject. In some embodiments, the methods include the steps of obtaining a biological sample from the subject; determining expression levels for two or more genes in the biological sample, wherein the two or more genes are selected from among the genes represented by SEQ ID NOs: 1-9; and calculating a ratio of the expression levels of the two or more genes determined in step (b) to thereby detect the presence of a multiple sclerosis syndrome in the subject. The presently disclosed subject matter also provides reagents and kits that can be used in the practice of the disclosed methods. Also provided are methods for assigning an uncharacterized subject to one of two populations of subjects and computer program products for identifying one or more ratio values that can be employed for assigning an uncharacterized subject to one of two populations of subjects.