HIV GP120 CRYSTAL STRUCTURE AND ITS USE TO IDENTIFY IMMUNOGENS

摘要

The present disclosure relates to stabilized forms of the HIV gpl20 envelope protein in complex with the broadly neutralizing CD4-binding site antibody bl2, to crystalline forms of the stabilized forms of the HIV gpl20 envelope protein in complex with the broadly neutralizing CD4- binding site antibody b 12, and to the high resolution structure obtained from these crystals by X-ray diffraction methods. Methods for identifying immunogenic polypeptides based on these structures are also disclosed.