| 摘要 |
Benzimidazole, benzoxazole and benzothiazole derivatives of formula (I), their isomers and acid addition salts are new. R1 = halo, OH, 1-6C alkyl (optionally substituted by aryl), trihalomethyl, aryl, methyl, CN, sulpho, amino(optionally mono- or di-substituted by 1-6C alkyl), optionally substituted aryl, acyl, aryl sulphonyl or alkyl sulphonyl, SH, 1-6C alkylthio, 1-6C trialkyl ammonium, aryloxy, arylthio, aryl amino carbonyl, aryl sulphonyl amino, aryl amino sulphonyl, aryl ureido, aryl thioureido, aryl sulphonyl, aryl sulphonyloxy, 3-7C cycloalkyloxy, 3-7C cycloalkylthio, 6-8C bicycloalkyloxy or 6-8C bicycloalkylthio (both optionally substituted by aryl), all aryl groups being optionally substituted; Ra, Rb = H, OH, or 1-6C alkyl (optionally substituted by aryl); X = O, S, or NR; R = H or 1-6C alkyl; R2 = imidazolyl, benzimidazol-1-yl, naphthyl, pyridyl, thiazolyl, oxazolyl, benzothiazolyl, benzoxazolyl, pyrrolyl, furyl, thienyl, imidazopyridinyl, triazolyl or tetrazolyl (all optionally substituted by 1 or more halo, 1-6C alkyl, 1-6C trihaloalkyl, 1-6C alkoxy, NO2, CN, COOH, 1-6C alkoxycarbonyl, OH, amino(optionally mono- or di-substituted by 1-6C alkyl, acyl, arylsulphonyl, or alkylsulphonyl) or phenyl or bicycloalkyl (both optionally substituted); and R'2 = H or aryl (optionally substituted). |
