Polyhydroxyalkylpyrazine derivatives their preparation and the medicaments comprising them

摘要

Novel medicaments contain, as active agent, one or more of 2,6-di-(polyhydroxyalkyl)-pyrazine derivatives of formula (I) (or their stereoisomers or salts with mineral or organic acids). (i) R1 = -CH(Ra)-CHOH-CHOH-CH2OH and R2 = -CH2-CHOH-CHOH-CH2OH; (ii) R1 = -CHOH-CHF-CHOH-CH2OH and R2 = -CH2-CHF-CHOH-CH2OH; (iii) R1 = -CHOH-CHOH-CHOH-Rb and R2 = -CH2-CHOH-CHOH-Rb; (iv) R1 = -CH2-CHOH-CHOH-CH2OH and R2 = -CH2-CHOH-CHOH-CH2OH; or (v) R1,R2 = the same -(CHOH)n-CH2OH; n = 1-4; Ra = 1-6C alkoxy or F; Rb = -COOH, -CONH2 or -CH2NH2. Compounds (I) (including salts and stereoisomers) are new, apart from the compound of formula (I') and (I; R1,R2 = 1,2,3,4-tetrahydroxybutyl).