发明名称 |
ANTAGONIST AGAINST TOLERANCE TO ANTICANCER DRUGS |
摘要 |
An ABC transporter protein expression inhibitor comprising, as the active ingredient(s), 0.001 to 100 nM of one or more members selected from among steroid hormones, compounds having a female hormone function, analogous compounds thereof and antagonistic inhibitors therefor; an anticancer composition containing this ABC transporter protein expression inhibitor and an anticancer drug; and cells useful in the development of an anticancer drug. The present invention provides a drug which inhibits the expression of an ABC transporter to thereby overcome resistance to anticancer drugs; cancer cells useful in screening such drugs; and an anticancer drug efficacious even against such a cancer as having acquired resistance to anticancer drugs.
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申请公布号 |
EP1785139(A1) |
申请公布日期 |
2007.05.16 |
申请号 |
EP20050776100 |
申请日期 |
2005.08.31 |
申请人 |
JAPANESE FOUNDATION FOR CANCER RESEARCH;KABUSHIKI KAISHA YAKULT HONSHA;SUGIMOTO, YOSHIKAZU |
发明人 |
TSUKAHARA, SATOMI;IMAI, YASUO;SUGIMOTO, YOSHIKAZU |
分类号 |
A61K31/56;A61K31/00;A61K31/05;A61K31/136;A61K31/337;A61K31/352;A61K31/353;A61K31/4745;A61K31/475;A61K31/553;A61K31/565;A61K31/566;A61K31/57;A61K45/00;A61P35/00;A61P43/00;G01N33/50 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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