发明名称 |
HEMATOPOIETIC STEM CELLS AND METHODS OF TREATMENT OF NEOVASCULAR EYE DISEASES THEREWITH |
摘要 |
<p>Isolated, mammalian, bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin<SUP>-</SUP> HSC) contain endothelial progenitor cells (EPC) capable of forming retinal blood vessels. At least about 50% of the cells in the isolated Lin<SUP>-</SUP> HSC population include cell surface markers for CD31 and c-kit. Up to about 8% of the cells can include the Sca-1 cell marker, and up to about 4% of the cells can include the Flk-1/KDR marker. The isolated Lin<SUP>-</SUP> HSC populations of the present invention are useful for treatment of ocular vascular diseases. The isolated Lin<SUP>-</SUP> HSC populations that have been transfected with therapeutically useful genes are also provided, which are useful for delivering genes to the eye for cell-based gene therapy.</p> |
申请公布号 |
EP1542536(A4) |
申请公布日期 |
2007.05.16 |
申请号 |
EP20030772195 |
申请日期 |
2003.07.25 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
FRIEDLANDER, MARTIN;OTANI, ATSUSHI;DASILVA, KAREN |
分类号 |
C12N15/09;A01N63/00;A61K35/12;A61K35/28;A61K48/00;A61P9/10;A61P27/02;C12N5/00;C12N5/02;C12N5/071;C12N5/078;C12N5/0789;C12N5/10;(IPC1-7):C12N5/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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