发明名称 |
CDK2 PROTEIN AND CDK2 PROTEIN COMPLEXES |
摘要 |
The present invention discloses complexes of the CDK2 protein with proteins identified as interacting with the CDK2 protein (CDK2 protein-IPs) by a modified, improved yeast two hybrid assay system. The proteins which were identified to interact with the CDK2 protein, and thus form complexes, included: cyclin I, ERH, hsReq*-1 and hsReq*-2, as well as derivatives, fragments analogs and homologs thereof. The invention also provides nucleic acids encoding the hsReq*-1 and hsReq*-2 nucleotide sequences, and proteins and derivatives, fragments and analogs thereof. Methodologies of screening these aforementioned complexes for efficacy in treating and/or preventing various diseases and disorders, particularly neoplasia and atherosclerosis, are also disclosed herein. |
申请公布号 |
WO9925829(A3) |
申请公布日期 |
1999.09.10 |
申请号 |
WO1998US24095 |
申请日期 |
1998.11.12 |
申请人 |
CURAGEN CORPORATION;YANG, MEIJIA;NANDABALAN, KRISHNAN;SCHULZ, VINCENT, PETER |
发明人 |
YANG, MEIJIA;NANDABALAN, KRISHNAN;SCHULZ, VINCENT, PETER |
分类号 |
A01K67/027;A61K31/711;A61K38/00;A61K39/395;A61K48/00;A61P9/10;C07K14/47;C07K19/00;C12N1/19;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12Q1/02;C12Q1/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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