| 摘要 |
<p>The invention relates to a solid pharmaceutical composition comprising a solid dispersion containing at least one active principle and a pharmaceutically-acceptable polymer matrix. The invention is characterised in that the pharmaceutically-acceptable polymer matrix comprises a mixture of (i) polydextrose, in the form of a continuous polydextrose phase, in order to favour the disintegration of the composition in an aqueous medium and (ii) at least one polymer other than polydextrose, in the form of a continuous phase, whereby the polydextrose is in a concentration of at least 20 wt.- % and the at least one polymer other than polydextrose is in a concentration of at least 20 wt.- % in relation to the total weight of the pharmaceutically-acceptable polymer matrix.</p> |
