CYCLIC DIARLY UREAS SUITABLE AS TYROSINE KINASE INHIBITORS.

摘要

The invention relates to novel compounds of Formula (I): wherein p is 1, 2 or 3;n is 0, 1, 2 or 3; mis0,1,2or3; A is CRc, S, NRc or O, where Rcis H or lower alkyl; X, Y and Z are each independently selected fro N or C-R3,wherein at least two of X, Y and Z are N; and each Ra is independently selectedfrom hydrogen and lower-alkyl; each Rb is hydrogen or lower-alkyl;G is a group Ar or represents CN or unsubstituted or substituted lower alkyl; Aris a saturated or unsaturated cyclic group, which is substituted or unsubstitutedand maybe a five or six membered monocyclic or a 8, 9, 10, 11 or 12 membered bicyclicor tricyclic ring and may contain 0, 1, 2 or 3 heteroatoms selected from O, N andS; and wherein the radicals have R1, R2, R3 andR4 have the meanings as defined herein, to salts, esters, N-oxidesor prodrugs thereof; and their use in the treatment of protein kinase dependentdiseases, their use in the manufacture of pharmaceutical compositions for usein the treatment of said diseases, me thods of use of diaryl urea derivatives inthe treatment of said diseases, pharmaceutical preparations comprising thesenovel diaryl urea derivatives, processes for the manufacture of the novel diarylurea derivatives, the use or methods of use of the novel diaryl urea derivativesas mentioned above, and/or these novel diaryl urea derivatives for use in thetreatment of the animal or human body.