| 摘要 |
<p>The present invention of compounds of formula (I), a stereochemically isomer ic form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R1 is C1-6alkyloxy, C2- 6alkenyloxy or C2-6alkynyl-oxy; R2 is hydrogen, C1-6alkyl C1-6alkyloxy; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkynyl, or L is a radical of formula -A1-R6-, A1-X-R7, -A1-Y-C(=O)-R9, or -A1-Y-C(-O)-NR11R12 wherein each A1 is C1-12alkanediyl; and R6 is hydrogen, cyano, C1-6alkylsulfonylamino, C3- 6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ring system; R7 is hydrogen, C1-6alkyl, hydroxy C1-6alkyl, C3-6cycloalkyl, or a heterocyclic ring system; X is O, S, SO2 or NR8; said R8 being hydrogen or C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy or hydroxy; Y is NR10 or a direct bond; said R10 being hydrogen, or C1-6alkyl; R11 and R12 each independently are hydrogen, C1-6alkyl, C3- 6cycloalkyl, or R11 and R12 combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4- morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditionswhich are related to impairment of gastric emptying.</p> |
