发明名称 |
REPLIKATIONSMANGELHAFTE MUTANTEN VON HERPESVIRUS |
摘要 |
<p>A herpesvirus vaccine comprising a mutated herpesvirus suspended in a pharmaceutically acceptable carrier. The mutated herpesvirus is capable of infecting cells of the mammal to be vaccinated, but incapable of completing a replicative cycle, and it is capable of eliciting a protective immune response in that mammal. The mutated herpesvirus is also capable of treating immunomodulatory or immunoregulatory diseases. The mutation occurs in at least one gene encoding a protein essential for replication of the virus, so that the mutation renders the virus replication defective.</p> |
申请公布号 |
AT360061(T) |
申请公布日期 |
2007.05.15 |
申请号 |
AT19950907356T |
申请日期 |
1995.01.09 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;DANA FARBER CANCER INSTITUTE |
发明人 |
KNIPE, DAVID;FINBERG, ROBERT;SIBER, GEORGE |
分类号 |
C12N15/09;A61K39/00;A61K39/245;A61P31/12;A61P31/22;C07K14/03;C12N7/04;C12N15/00;C12P21/02;C12R1/92;(IPC1-7):C12N7/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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