发明名称 |
Method of dideoxyinosine production with the aid of adenosine deaminase enzyme |
摘要 |
A method of making didanosine (ddI) including the steps of: (a) obtaining an enzyme expressing ddA deaminase activity; (b) immobilizing the enzyme onto an insoluble support; (c) contacting the enzyme with a dideoxyadenosine (ddA) solution of at least about 4% weight volume ddA in water for a time and under conditions to produce a ddI solution; and (d) isolating the ddI from the ddI solution. Optionally, the ddI mother liquor is reused in subsequent runs to improve yield. |
申请公布号 |
PL381265(A1) |
申请公布日期 |
2007.05.14 |
申请号 |
PL20040381265 |
申请日期 |
2004.02.27 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
SKONEZNY PAUL M.;POLITINO MICHAEL;LIU SUO W.;BOYLE ALFRED W.;CHEN JASON G.;STEIN GREGORY L.;FRANCESCHINI THOMAS;ANDERSON WENDY L. |
分类号 |
C12P19/40;C07H19/16;C07H19/167 |
主分类号 |
C12P19/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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