发明名称 |
Transglutaminase mediated conjugation of peptides |
摘要 |
Methods for conjugating peptides are provided comprising i) reacting a peptide with a first compound comprising a functional group in the presence of a transglutaminase capable of incorporating said compound into the peptide to form a transaminated peptide, and ii) reacting said transaminated peptide with e.g. a functionalized polymer capable of reacting with the functional group incorporated in the peptide in the enzymatic reaction.
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申请公布号 |
US2007105770(A1) |
申请公布日期 |
2007.05.10 |
申请号 |
US20060484474 |
申请日期 |
2006.07.11 |
申请人 |
NOVO NORDISK A/S |
发明人 |
JOHANSEN NILS L.;ZUNDEL MAGALI;DORWALD FLORENCIO Z. |
分类号 |
A61K38/27;C07K14/61;C12P21/06 |
主分类号 |
A61K38/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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