CONTROLLED RELEASE COMPOSITIONS COMPRISING A COMBINATION OF ISOSORBIDE DINITRATE AND HYDRALAZINE HYDROCHLORIDE

摘要

The invention relates to a controlled release composition comprising a
combination of isosorbide dinitrate and hydralazine, such as hydralazine
hydrochloride, that in operation delivers the drug in a pulsed or multi-modal
manner for the treatment of angina, ischaemic heart disease, arterial
hypertension and related disease conditions. Preferably, the isosorbide
dinitrate and hydralazine hydrochloride can be released from the dosage form
in an erodable, diffusion and/or osmotic-controlled release profile.