发明名称 |
Ligand-pseudoreceptor system for generation of adenoviral vectors with altered tropism |
摘要 |
In accordance with the present invention, there is provided a modified virus ablated of its natural receptors interactions with an unmodified or non-naturally occurring cell, said modified virus comprising a non-native polypeptide, said modified virus having an altered tropism conferred by said non-native peptide, and replicating only in cells that can interact with said non-native peptide, said virus being incapable of infecting a cell through a CAR-dependent entry pathway. There is also provided a modified cell line for replicating the modified virus. These two together can be advantageously put into practice in the field of medicine and more particularly in gene therapy.
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申请公布号 |
US2007104732(A1) |
申请公布日期 |
2007.05.10 |
申请号 |
US20040576500 |
申请日期 |
2004.10.22 |
申请人 |
MASSIE BERNARD;ZENG YUE;O'CONNNOR-MCCOURT MAUREEN |
发明人 |
MASSIE BERNARD;ZENG YUE;O'CONNNOR-MCCOURT MAUREEN |
分类号 |
A61K39/12;A61K48/00;C07K14/075;C07K14/245;C07K14/705;C07K14/71;C12N;C12N5/10;C12N7/00;C12N7/01;C12N15/86;C12N15/861;C12Q1/70 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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