发明名称 |
NON-TOXIC MUTANTS OF PATHOGENIC GRAM-NEGATIVE BACTERIA |
摘要 |
A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional HtrB protein, resulting in a mutant that lacks one or more secondary acyl chains and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, or the endotoxin isolated therefrom, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation.
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申请公布号 |
US2007104736(A1) |
申请公布日期 |
2007.05.10 |
申请号 |
US20050087235 |
申请日期 |
2005.03.23 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION, A IOWA CORPORATION |
发明人 |
APICELLA MICHAEL A.;SUNSHINE MELVIN G.;LEE NA-GYONG;GIBSON BRADFORD W. |
分类号 |
A61K48/00;C12N15/09;A61K31/739;A61K39/00;A61K39/02;A61K39/09;A61K39/095;A61K39/102;A61K39/104;A61K39/106;A61K39/112;A61K39/116;A61P31/04;C12N1/21;C12N9/10;C12N15/01;C12R1/01 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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地址 |
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