| 摘要 |
FIELD: medicine, hematology, polypeptides, pharmacy. ^ SUBSTANCE: invention relates to composition containing factor VII or factor VII-related polypeptide and factor XI or factor XI-related-polypeptide, sets containing indicated compounds and to using composition used in treatment of bleeding. Pharmaceutical composition contains the effective dose of factor VII or factor VII-related polypeptide, and factor XI or factor XI-related polypeptide. Invention provides the following effects: (1) design of composition that can be used effectively in treatment or prophylaxis of bleeding and blood coagulation disorders being oral composition preferably; (2) design of compositions as the single dosed formulation that can be used effectively in treatment or prophylaxis of bleeding or as a procoagulant agent; (3) design of compositions possessing the synergetic effect, design of treatment methods or sets that promote to the development of synergetic effect; (4) design of compositions, methods for treatment and sets without adverse effects, such as the high level of systemic activation of the blood coagulation system. ^ EFFECT: valuable medicinal properties of pharmaceutical composition. ^ 43 cl, 1 tbl, 4 dwg, 2 ex |
