COMBINATION OF AN ALDOSTERONE RECEPTOR ANTAGONIST AND AN ENDOTHELIN RECEPTOR ANTAGONIST AND/OR ENDOTHELIN CONVERTING ENZYME INHIBITOR

摘要

Novel combinations, compositions, and therapeutic methods of treatment and/or prophylaxis of a hypertension, cardiovascular disease, renal dysfunction, edema, cerebrovascular disease, or insulinopathy pathological conditions in a subject, wherein the methods comprise the administration of a combination of one or more aldosterone receptor antagonists and one or more endothelin receptor antagonist and/or ECE inhibitors selected from a specific group of compounds described herein.