PROCESS FOR PRODUCTION OF BENZYLOXYPYRROLIDINE DERIVATIVE, AND PROCESS FOR PRODUCTION OF HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE

摘要

Disclosed are: a process for production of a benzyloxypyrrolidine derivative with high yield and in a safe manner; a hydrochloride salt powder of a benzyloxypyrrolidine derivative; and a process for production of the hydrochloride salt powder with high yield and in a safe manner. The process for production of a benzyloxypyrrolidine derivative represented by the general formula (2) comprises reacting a pyrrolidinol derivative represented by the general formula (1) with a benzyl halide derivative in the presence of an alkali metal hydroxide, wherein the reaction is performed under either of the following conditions (A) and (B): (A) in an aprotic polar solvent; and (B) in an aliphatic ether solvent containing a phase transfer catalyst. [Chemical formula 1] (1) [Chemical formula 2] (2)