CURCUMINOID COMPOUNDS FOR INHIBITING PLASMINOGEN ACTIVATOR INHIBITOR-1

摘要

Pharmaceutical compounds which are analogs of curcumin [bis-l,7-(4-hydroxy-3-methoxyphenyl)-hepta-l,6-diene-3,5dione] which act as inhibitors of plasminogen activator inhibitor- 1 (PAI-I) and thus are useful in the treatment and the prophylactic of various thrombotic related disease conditions, including deep vein thrombosis, coronary artery disease, pulmonary fibrosis and polycystic ovary syndrome