IDENTIFICATION OF COMPOUNDS MODULATING THE SMYD3 TRANSFERASE FOR THE TREATMENT OF CANCER
摘要
The present invention features a method for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of retinoblastoma by SMYD3. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified. N-terminal truncated forms of SMYD3 (alias ZNFN3A1) have higher methylating activity. Lys 824 is a preferred methylation site on the RB1 protein for SMYD3.
申请公布号
WO2007004526(A3)
申请公布日期
2007.05.10
申请号
WO2006JP313038
申请日期
2006.06.23
申请人
ONCOTHERAPY SCIENCE, INC.;THE UNIVERSITY OF TOKYO;NAKAMURA, YUSUKE;FURUKAWA, YOICHI;HAMAMOTO, RYUJI;NAKATSURU, SHUICHI