PROCESS FOR THE PREPARATION OF N-(SUBSTITUTED PHENYL)-3-ALKYL-, ARYL- AND HETEROARYLSULFONYL-2-HYDROXY-2-ALKYL- AND HALOALKYLPROPANAMIDE COMPOUNDS

摘要

The present invention provides an improved process for the preparation of N-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds of formula I that exhibit antiandrogenic activity and are useful in the treatment of malignant or benign prostatic disease or of androgen dependent disease conditions such as acne, hirsutism or seborrhea.