Ascending-dose dosage form

摘要

A dosage form and a method are disclosed for delivering to a human patient a drug in an ascending amount over time. In particular, the invention provides a dosage form having a length greater than its width, the dosage form comprising:
(a) a first layer comprising 10 ng to 700 mg of a drug selected from methylphenidate or a pharmaceutically acceptable salt thereof;
(b) a second layer comprising 80% to 95% of a hydrophilic-expandable polymer;
(c) a wall comprising a semipermeable composition that surrounds the first and second layer;
(d) an exit in the wall communicating with the first layer for delivering the drug; and wherein the dosage form when in operation administers the drug in an ascending rate over time.