AEROSOL DRUG DELIVERY DEVICE INCORPORATING PERCUSSIVELY ACTIVATED HEAT PACKAGES
摘要
Aerosol drug delivery devices (10) incorporating percussively activated heat packages (32) are disclosed. The heat packages include a percussive igniter (40) and a fuel (50) capable of undergoing an exothermic oxidation-reduction reaction when ignited by the percussive igniter. The drug delivery devices disclosed can be activated by an actuation mechanism to vaporize a thin solid film (56) comprising a drug disposed on the exterior of a heat package. Metal coordination complexes of volatile drugs, and in particular nicotine, from which the drug can be selectively vaporized when heated are also disclosed. The use of aerosol drug delivery devices comprising thin films of nicotine metal salt complexes for the treatment of nicotine craving and for effecting smoking cessation are also disclosed.
申请公布号
EP1781360(A1)
申请公布日期
2007.05.09
申请号
EP20040781102
申请日期
2004.08.12
申请人
ALEXZA PHARMACEUTICALS, INC.
发明人
HALE, RON L.;LEI, MINGZU;SHARMA, KRISHNAMOHAN;LLOYD, PETER M.;MUNZAR, PATRICK;SOLAS, DENNIS;STRACKER, MATTHEW D.