Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist

摘要

The present invention relates to compounds of the Formula (I)
<Chemistry id="chema01" num="0001"><Image id="ia01" he="18" wi="29" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
wherein Q is:
<Chemistry id="chema02" num="0002"><Image id="ia02" he="33" wi="125" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.