| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to novel compounds chosen from the following substances: Ph-(3-Cl)-(5-OCHF2)-(R)-CH(OH)C(O)-Aze-Pab(OMe); Ph-(3-Cl)-(5-OCHF2)-(R)-CH(OH)C(O)-Aze-Pab(OH), and Ph-(3-Cl)-(5-OCHF2)-(R)-CH(OH)C(O)-Aze-Pab or their pharmaceutically acceptable salts. Proposed compounds inhibit thrombin and can be used in pharmaceutical composition for treatment state wherein thrombin inhibition is required. ^ EFFECT: valuable medicinal properties of compounds. ^ 16 cl, 49 ex |
