发明名称 |
ADDUCT OF FLUORESCENT DYE AND TUMOR AVID TETRAPYRROLE |
摘要 |
A compound having preferential localization in tumor tissue relative to normal tissue, a preferential electromagnetic absorption at a wavelength between about 660 and 900 nm, and a fluorescence at a wavelength shifted from the preferential absorption by at least +30 nm and preferably at least +50 nm. The compound further preferably destroys tumor tissue in which it is absorbed when exposed to light at its preferential absorption wavelength. In a preferred embodiment of the invention, the compound is a conjugate of a tumor avid tetrapyrrole compound with a fluorescent dye, and more preferably the fluorescent dye is an indocyanine dye such as indocyanine green. The tumor avid tetrapyrrole compound is preferably a porphyrin derivative selected from the group consisting of chlorins, bacteriochlorins, purpurins and derivatives thereof. |
申请公布号 |
EP1781170(A1) |
申请公布日期 |
2007.05.09 |
申请号 |
EP20050773299 |
申请日期 |
2005.07.13 |
申请人 |
HEALTH RESEARCH, INC. |
发明人 |
PANDEY, RAVINDRA, K.;CHEN, YIHUI;POTTER, WILLIAM;OSEROFF, ALLAN |
分类号 |
A61K41/00;A61K49/00;C07D487/22 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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