| 摘要 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; X is carbon, Y is CH and is a double bond; or X is CH, Y is CH<SUB>2 </SUB>or oxygen and is a single bond; or X is nitrogen, Y is CH<SUB>2 </SUB>and is a single bond; R 1 is halogen, cyano, or C<SUB>1-6 </SUB>alkoxy; a is 0,1, 2 or 3 ; b is 0 or 1 ; R 2 is hydrogen, C<SUB>1-6 </SUB>alkyl, C<SUB>1-6 </SUB>alkanoyl, fluoroC<SUB>1-6 </SUB>alkanoyl, C<SUB>1-6 </SUB>alkylsulfonyl, fluoroC<SUB>1-6 </SUB>alkylsulfonyl, carbamoyl, C<SUB>1-6 </SUB>alkylcarbamoyl or arylC<SUB>1-6 </SUB>alkyl; and R 3 , together with the nitrogen atom to which it is attached, forms an optionally substituted 5 to 7 membered heterocyclic group fused to the benzene ring. Methods of preparing the compounds and uses of the compounds in therapy, in particular for a CNS disorder such as depression or anxiety, are also disclosed.
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