| 摘要 |
Objects of the present invention are to create compounds having urea structure as basic structure and having a sulfur atom and an amide bond in side chains and to find pharmacological effects thereof, particularl y TNF-.alpha. production inhibitory effects. The present invention provides compounds represented by the following formula [I] wherein R' is H, alkyl, aromatic, R A-CO-, R C-S- or t he formula [II]; R2, R3 and R4 are H, alkyl, alkenyl, cycloalkyl, cycloalkenyl or aromatic; R5 and R5 are H, alkyl, alkenyl, cycloalkyl, cycloalkenyl or aromatic; R5 and R6 can together form a nonaromatic heterocyclic ring; R7 is H, alkyl, cycloalkyl, hydroxy, mercapto, phenyl, R B-O-, R C-S-, R D-COS-, R E- OCO-, R F-N(R G)- or -CONHOH; and A1 and A2 are alkylene.
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