发明名称 |
Crystal structure of aurora a kinase and uses thereof |
摘要 |
The invention provides crystalline forms of a polypeptide corresponding to the catalytic domain of Aurora kinase. The active site ATP binding pocket is defined by its amino acid residues and their atomic coordinates. This structure may be used to select or design chemical modulators of Aurora kinase, particularly Aurora inhibitors. These modulators may be used to treat diseases of cell proliferation, e.g. cancer.
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申请公布号 |
US7214518(B2) |
申请公布日期 |
2007.05.08 |
申请号 |
US20040491854 |
申请日期 |
2004.10.29 |
申请人 |
ASTRAZENECA AB |
发明人 |
ANDERSON MALCOM;KEEN NICHOLAS JOHN;PANNIFER ANDREW DAVID BRUCE;PAUPTIT RICHARD ALEXANDER;ROWSELL SIAN |
分类号 |
C12N9/00;A61K31/517;A61K38/43;A61P35/00;A61P43/00;C07D239/94;C12N9/12 |
主分类号 |
C12N9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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