| 发明名称 |
E. coli O157:H7 C1-INH-binding protein and methods of use |
| 摘要 |
Disclosed is a pO157 plasmid-specified polypeptide found in E. coli EDL933 and other E. coli that binds to and cleaves C1-esterase inhibitor, and antibodies specific for the polypeptide. Also disclosed are methods employing the polypeptide for diagnosing enterohemorrhagic E. coli infection, identifying potential inhibitors of its activity, and reducing viscosity of material containing glycosylated polypeptides.
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| 申请公布号 |
US7214479(B2) |
申请公布日期 |
2007.05.08 |
| 申请号 |
US20040786445 |
申请日期 |
2004.02.25 |
| 申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
WELCH RODNEY A.;LATHEM WYNDHAM W.;GRYS THOMAS E. |
| 分类号 |
C12Q1/00;A61K39/00;C07K14/245;C07K16/12;C12N9/48;C12N9/52;C12Q1/37;C12Q1/68;G01N33/573 |
主分类号 |
C12Q1/00 |
| 代理机构 |
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代理人 |
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