发明名称 |
Methods for identifying human cell lines useful for endogenous gene activation, isolated human cell lines identified thereby, and uses thereof |
摘要 |
The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
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申请公布号 |
US7214532(B2) |
申请公布日期 |
2007.05.08 |
申请号 |
US20030351397 |
申请日期 |
2003.01.27 |
申请人 |
ROCHE DIAGNOSTICS, GMBH |
发明人 |
STERN ANNE;BRANDT MICHAEL;HONOLD KONRAD;AUER JOHANNES;KOLL HANS;FRANZE REINHARD;PESSARA ULRICH |
分类号 |
C12N15/00;A61K38/00;C07K14/505;C12N5/02;C12N5/08;C12N15/10;C12N15/62;C12P21/00 |
主分类号 |
C12N15/00 |
代理机构 |
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