发明名称 |
Compositions and methods for hydroxylating epothilones |
摘要 |
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
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申请公布号 |
US7214527(B2) |
申请公布日期 |
2007.05.08 |
申请号 |
US20040915172 |
申请日期 |
2004.08.09 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BASCH JONATHAN DAVID;CHIANG SHU-JEN DAVID;LIU SUO-WIN;NAYEEM AKBAR;SUN YUHUA;YOU LI |
分类号 |
C12N1/20;C07H21/04;C07K14/79;C12N9/02;C12N15/74;C12P17/18 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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