发明名称 Methods for enhancing the efficacy of cytotoxic agents through the use of HSP90 inhibitors
摘要 The administration of cytotoxic agents followed by the administration of heat shock protein 90 inhibitors, such as ansamycins, has a synergistic effect on the growth inhibition of cells. This synergy occurs at doses of each cytotoxic agent that normally only causes minimal growth inhibition of cells. Such combination therapy thus allows one to use lower doses of cytotoxic agents to avoid or reduce their respective toxicity to patients without compromising their growth inhibitory effects. Thus, these combinations can be used for the treatment of an animal, preferably a mammal, that has a cell proliferative disorder, whether the cells have wild-type Rb or are Rb deficient or Rb negative. One such method, directed to treating cell proliferative disorders includes the step of administering a therapeutic effective amount of a cytotoxic agent followed by administering a therapeutic effective amount of a heat shock protein 90 inhibitor. The cytotoxic agent may be a microtubule-affecting agent, topoisomerase II inhibitor, a platinum complex, paclitaxel, or a paclitaxel derivative. The HSP90 inhibitor may be an ansamycin, radicicol or a synthetic compound that binds to the ATP-binding site of HSP90.
申请公布号 US7211562(B2) 申请公布日期 2007.05.01
申请号 US20030415878 申请日期 2003.05.01
申请人 SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH 发明人 ROSEN NEAL;MUNSTER PAMELA NATHALIE
分类号 A61K35/00;A61K45/06;A61K31/282;A61K31/337;A61K31/365;A61K31/395;A61K31/505;A61K31/704;A61K33/24;A61K38/00;A61K38/43;A61K41/00;A61P11/00;A61P15/00;A61P35/00;A61P43/00 主分类号 A61K35/00
代理机构 代理人
主权项
地址