发明名称 |
Methods and construction and screening of libraries of chemokine variants |
摘要 |
The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
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申请公布号 |
US7211564(B2) |
申请公布日期 |
2007.05.01 |
申请号 |
US20040791814 |
申请日期 |
2004.03.04 |
申请人 |
UNIVERSITE DE GENEVE |
发明人 |
GOROCHOV GUY;HARTLEY OLIVER;DORGHAM KARIM;DEBRE PATRICE;OFFORD ROBIN |
分类号 |
A61K38/00;A61K38/04;C07K14/00;C07K14/52;C12N1/21;C12N15/10;C40B30/04;C40B40/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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