New type of human immuno-deficiency virus, infections for T4 cells - and derived antigens, immunogens, monoclonal antibodies and nucleic acid sequences, e.g. for diagnosis of AIDS

摘要

18.3.86, 13.2.86, 6.2.86, 22.1.86-FR-004215, 003881, 001985, 001635, 000911) New HIV-2 (human innunodeficiency virus), or its variants, are infectious for human T4 lymphocytes and have the morphological and immunological characteristics of the viruses deposited as I-502, -532, -642, and -643 (CNCM). Also new are (1) antigens (Ag), forming a single bond in polyacrylamide gel electrophoresis, contg. an epitope recognised by the serum of a carrier of HIV-2 antibodies; (2) immunogens contg. HIV-2 glycoprotein; (3) monoclonal antibdoies (MAb) which specifically recognise (Ag; (4) the hybridomas which produce MAb; and (5) nucleic acid sequences, opt. labelled, derived from at least part of the RNA of HIV-2, or its variants.