发明名称 |
A PROCESS FOR THE CONVERSION OF ECHINOCANDIN CLASS OF PEPTIDES TO THEIR C4-HOMOTYROSINE MONODEOXY ANALOGUES |
摘要 |
<p>The invention relates to a process for the conversion of echinocandin class of peptides to their C4-homotyrosine monodeoxy analogues, particularly mulundocandin to deoxymulundocandin, which consists of a single step selective reduction of C4-htyr (homotyrosine) hydroxyl group of echinocandins to their monodeoxy analogues under neutral conditions without prior protection/deprotection of the equally facile C5-Orn (ornithine) hydroxyl group and purification of the monodeoxy compound from the crude reaction mixture.</p> |
申请公布号 |
SI1073675(T1) |
申请公布日期 |
2007.04.30 |
申请号 |
SI19990030951T |
申请日期 |
1999.04.22 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
MUKHOPADHYAY TRIPTIKUMAR;JAYVANTI KENIA;KUMAR ERRA KOTESWARA SATYA VIJAYA |
分类号 |
C07K7/56 |
主分类号 |
C07K7/56 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|